Hydro-alcoholic extract of Ochradenus baccatus exhibits anti-oxidative and anti-inflammatory properties and inhibits enzyme of uric acid metabolism: Implications for bioactive molecules

Traditional medicines have been an accessible, affordable, and culturally acceptable model of healthcare that is trusted acrossthe globe in terms disease management, symptoms relief patient satisfaction. The natural products derived from plant sources arethe fundamental ingredients traditional folk medicine serve as lead compounds or pharmacophore for most effective drugs inmodern pharmacology treatment infectious chronic diseases. Ochradenus baccatus, which belongs to family Resedaceae, aperennial shrub, widely distributed the arid regions Arabian Peninsula finds mention reproductivehealth, inflammation infection. Results: As a proof-of-concept, this study has investigated various bioactive properties plantvis-à-vis anti-oxidative, anti-inflammatory inhibition xanthine oxidase using standard vitro experimental models. bioactivemolecules found extract included flavonoids, phenolics, tannins, saponins alkaloids varying quantities, are known tobe associated with multitude pharmacological properties. Our results show caused progressive DPPHradical neutralizes superoxide anions dose-dependent manner. demonstrated its redox-active potential by means itsability reduce Cu (II) (I) detected bathocuproine, (I)-specific sequestering agent. Progressive doses extractsinhibited denaturation protein (a factor inflammation), maximum 70.6% observed at concentrationof 600 μg/ml, after effect plateaued further doses. Moreover, displayed inhibitory property againstthe enzymatic activity 66% dose 300 μg/ml. Conclusion: Inhibition ofxanthine reduces hyperuricemia patients gout nephrolithiasis it alleviates tendency salt accumulation inthe joints kidney. interest escalating exploring novel plantsof significant stride knowledge evidence-based practice